Click OK to dismiss this dialog, and then click OK on the properties dialog.On the bottom half of the 'Permissions' dialog, click 'Full Control' for the user you just added.If not, double check your login name from step 7. Click 'Check Names' and if the name becomes underlined, you did it right! Click OK.Type your login name (if you log in as 'bobsmith' then you'd type 'bobsmith' here).Right click on the 'Games' folder, and choose 'Properties'.If the 'Games' folder does not exist, right click, choose 'New Folder' and name it 'Games'.You can do this if you have administrator rights by: Just right click, and choose the 'Run as Administrator' option. This way, it will have permissions to write to the root of C:\, and then you can create the files/folders there.
They want you to install into a subfolder of C:\, and if you don't have administrator rights, chances are you can't create the 'Games' folder you need (C:\Games).
The root cause is that the default folder that Nexus Mod Manager wants to install into is not typically writable by normal users.
I ran into this problem today, and I've come up with a few solutions.